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Descrição de um protocolo experimental para estudos cardiofisiológicos em camundongos

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Author(s): Sarah Soares de Castro | Laíse Oliveira Resende | Márcia Artiaga Colantoni | Lívia Alves Martins | Aldo Rogelis Aquiles Rodrigues | Valdo José Dias | João Batista Destro Filho

Journal: Exacta
ISSN 1678-5428

Volume: 9;
Issue: 1;
Start page: 89;
Date: 2011;
Original page

ABSTRACT
This paper describes a preparing and application electrode method for cardiophysiological study performed in mice in order to relate the results obtained with these experiments to humans by means of comparative physiology. The study consisted of monitoring the state of mouse cardiophysiological parameters using an electrocardiograph during intravenous administration of subanesthetic ketamine. The final result was obtained by spectral analysis which outlined changes in cardiac activity of the animal after the drug injection, leading to the reduction of RR-interval duration and to the sharp fall in the low frequency (LF) component signal. This result points out that there was an increase in heart rate after pretreatment of atropine and subsequent administration of ketamine.
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