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DESIGN AND CHARACTERIZATION OF TRANSMUCOSAL DRUG DELIVERY SYSTEM OF GLIBENCLAMIDE

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Author(s): Sarfaraz Md | P Venubabu | Hiremath Doddayya | Udupi R H

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 116;
Date: 2011;
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Keywords: Glibenclamide | mucoadhesive buccal tablets | direct compression | in-vitro bioadhesion strength | swelling index | in-vitro release.

ABSTRACT
Buccal drug delivery has been considered as an alternative to oral route for compounds subjected to degradation in the gastrointestinal tract or hepatic first pass metabolism. Glibenclamide, an oral hypoglycemic agent of the sulphonylurea group is frequently prescribed for the treatment of late-onset (non-insulin dependent) diabetes mellitus. In the present investigation, an attempt was made to develop mucoadhesive buccal tablets of glibenclamide by direct compression method using bioadhesive polymers like Carbopol 934P, HPMC K4M and NaCMC. Preformulation and micromeritic studies were carried out. The physical characteristics, surface pH, in-vitro bioadhesion strength, swelling index and in-vitro release of formulated tablets were dependent on characteristics and composition of bioadhesive materials used. The formulation F2 containing Carbopol 934P, HPMC K4M and mannitol was found to be promising and exhibited an in vitro drug release of 95.94% in 8 hrs along with satisfactory bioadhesion strength (3.68 gms). Short-term stability studies on the promising formulation indicated no significant changes in drug content and in vitro dissolution characteristics. The n values of all formulations were in the range of 1.327 – 1.518, indicating non-Fickian super case II type transport mechanism. FT-IR and DSC studies revealed absence of any chemical interaction between drug and polymers used.
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