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Design, development and evaluation of Pulsatile Drug Delivery of flurbiprofen microsph

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Author(s): J.Kausalya1, J.Lakshmi Eswari2, S.Padma Priya3, Kumaravel Rajan4, V.Vaijayanthi5,Anusha Rupenagunta6, B.Senthilnathan7*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 6;
Start page: 1614;
Date: 2011;
Original page

Keywords: Flurbiprofen | microspheres | pulsatile drug delivery | NSAID‘s | rheumatoid arthritis.

ABSTRACT
An oral controlled onset extended release dosage form intended to approximate the chronobiology of rheumatoid arthritis is proposed for site-specific release to the colon. The multiparticulate system consisting of drug –loaded cellulose acetate cores encapsulated within Eudragit S-100 microspheres was designed for chronotherapeutic delivery of flurbiprofen. Drug –loaded cellulose acetate cores were prepared by emulsion solvent evaporation technique in an oily phase at different drug: polymer ratios (1:1, 2:1 and 3:1). These cores were successfully microencapsulated with Eudragit S-100 following the same technique at the core: coat ratio of 1:5. Scanning electron microscopy (SEM) revealed that the cellulose acetate cores were discrete, uniform and spherical with smooth surface. In vitro drug release studies of Eudragit microspheres were performed in different pH conditions following pH progression method for a period of 18h. The release studies indicated that the microspheres possess both pH sensitive and extended release properties, showing limited drug release before pH7.4, following which the cellulose acetate cores effectively controlled the drug release for a period of 12h in pH7.4. The release of flurbiprofen from Eudragit microspheres in pH7.4 depended on the cellulose acetate levels and were characterized bykorsemayer-peppas diffusion model (super case-II transport).
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