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Design and evaluation of gastro retentive floating beads of ranitidine hydrochloride

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Author(s): M. Vani | A. Meena | F. Godwin Savio | Mohana Priya | Nancy

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 01;
Issue: 01;
Start page: 01;
Date: 2010;
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Keywords: Ranitidine hydrochloride | Gastro retentive floating beads | CaCO3 | HPMC | Sodium alginate

ABSTRACT
A gastro retentive floating beads of ranitidine hydrochloride were formulated to increase the residence time in stomach and to sustain the release behavior of the drug and increase drug bioavailability .The ranitidine hydrochloride floating beads were done by extrusion congealing method, because the major site of absorption of ranitidine hydrochloride is being the stomach, to extend the period of residence of the drug in the stomach to leave maximum absorption. Nine formulations of ranitidine hydrochloride floating beads were formulated by extrusion congealing technique using different percentage of gas forming agent and polymers, HPMC and sodium alginate. The content of drug release was done by UV spectrophotometer at 322 nm. The particle size analysis was done by vernier caliper which was found to be in the range of 0.1-0.3. In vitro drug release of ranitidine hydrochloride, for F2 (3%w/w HPMC) and F6 (4%w/w HPMC) were found to be 80.12% and 81.10% respectively, at the end of 480 m in simulated gastric fluid (pH 1.2). The percentage drug entrapment and drug content of the formulated beads were found to be satisfactory by this method. From the study it was concluded that the gastro retentive drug delivery system designed as floating beads could be suitable drug delivery system for Ranitidine HCl. Further the in vivo absorption studies will confirm the suitability of the formulated dosage form.
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