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Design and Evaluation of Mouth Dissolving Tablets of Carbamazepine

Author(s): K. Ramanjaneyulu1*, Pamula Reddy B, V.Ravikiran, K R Mohan babu, L Srinivas, K. Yamini saraswathi, S.srujana, Prathima patil

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3004;
Date: 2011;
Original page

Keywords: Carbamazepine | Dissolution rate | Direct compression | Effervescent method.

Carbamazepine is a dibenzazepine derivative with anti-epileptic and psychotropic properties. It is also used in the treatment of trigeminal neuralgia and pain.In this present study was undertaken with an intention to develop mouth dissolving tablets of Carbamazepine by direct compression and effervescent methodsalong with superdisintegrants. The drug calibration curve was plotted and formulations were coded as F1, F2 and F3. The preformulation parameter was notedand evaluation parameters like average weight, hardness, and friability and in-vitro dispersion times were noted and meet the IP requirements. The hardness ofthe tablets prepared by sublimation method (2.5 to 3.0 kg/cm2) because of their porous structure. A friability value below 1% was an indication of goodmechanical resistance of the tablets against abrasion and mechanical shock. The formulation F2 were found to be promosing displayed an in vitro dispersiontime of

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