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Design; Synthesis and Antihypertensive activity of 4'-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid

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Author(s): M. C. Sharma | D.V. Kohli | Smita Sharma

Journal: International Journal of Advances in Pharmaceutical Sciences
ISSN 0976-1055

Volume: 1;
Issue: 3;
Date: 2011;
Original page

Keywords: Benzimidazoles | biphenyl-2-carboxylic acid | angiotensin II | hypertension

ABSTRACT
In the present study, a series of 4`-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid derivatives are synthesized by A one-step coupling of substituted benzimidazoles with biphenyl carboxylic moiety mediated by potassium carbonate is described. The biphenyl carboxylic moiety was prepared from 9-H-fluorenone and substituted benzimidazoles were synthesized from o-phenylenediamine with anthranilic acid.Keywords: Benzimidazoles, biphenyl-2-carboxylic acid, angiotensin II, hypertension

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