Academic Journals Database
Disseminating quality controlled scientific knowledge

Design, synthesis and antimicrobial screening of s-Triazinyl piperazine and piperidine derivatives

ADD TO MY LIST
 
Author(s): Rahul V. Patel | Premlata Kumari | K. H. Chikhalia

Journal: International Journal of Advances in Pharmaceutical Sciences
ISSN 0976-1055

Volume: 1;
Issue: 4;
Date: 2011;
Original page

Keywords: 2 | 4 | 6-trichloro-1 | 3 | 5-triazine | 8-hydroxy quinoline | 4-amino benzonitrile | anti microbial activity.

ABSTRACT
A series of ten 2,4,6-trisubstituted s-triazines have been synthesized selectively with nucleophilic reagents such as 4-amino benzonitrile, 8-hydroxy quinoline and different piperazine as well as piperidine substituents on the C-6 position of s-triazine ring. The title compounds were then examined for their in vitro microbial activity against 2 gram –Ve bacteria (E. Coli, P. Aeruginosa), 2 gram +Ve bacteria (S. Aerues, B. subtilis) and 2 fungal species (C. Albicans and A. niger). The most of the synthesized compounds have shown potent anti-bacterial and anti-fungal activities. Structure of final scaffolds has been affirmed by means of IR, 1H NMR, 13C NMR and elemental analysis.Keywords: 2,4,6-trichloro-1,3,5-triazine, 8-hydroxy quinoline, 4-amino benzonitrile, anti microbial activity.
Affiliate Program     

Tango Rapperswil
Tango Rapperswil