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Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid

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Author(s): Jiuyang Zhao | Wei Li | Rui Ma | Shaopeng Chen | Sumei Ren | Tao Jiang

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 14;
Issue: 8;
Start page: 16851;
Date: 2013;
Original page

Keywords: glycuronic acid | DNA bis-intercaltor | synthesis and design

ABSTRACT
A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding properties of these compounds to calf thymus DNA (CT-DNA) have been investigated by UV-absorption and fluorescence spectroscopy. The results indicated that all the target compounds can interact with CT-DNA, and the acridine derivative, 3b, showed the highest key selection vector (KSV) value, which suggested that compound 3b binds most strongly to CT-DNA.

Tango Jona
Tangokurs Rapperswil-Jona

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