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Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

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Author(s): Nathan Gooch | Randon Michael Burr | Dolly J. Holt | Bruce Gale | Balamurali Ambati

Journal: Journal of Functional Biomaterials
ISSN 2079-4983

Volume: 4;
Issue: 1;
Start page: 14;
Date: 2013;
Original page

Keywords: CDR | capsular bag | drug delivery | biocompatibility

ABSTRACT
The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
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