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DETECTION OF DNA DAMAGE IN OBESE CARDIOVASCULAR DISEASE PATIENTS AND COMPARISON BETWEEN GENDERS: A CASE-CONTROL STUDY

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Author(s): GANDHI G., KAUR J. and MAHAJAN N.

Journal: International Journal of Genetics
ISSN 0975-2862

Volume: 3;
Issue: 2;
Start page: 66;
Date: 2011;
Original page

Keywords: SCGE/comet assay | Damage Frequency | Damage Index

ABSTRACT
Background- Obesity and cardiovascular disease (CVD) with the increased stress/ inflammation may cause DNA damage posing risk for malignancy hence assessment of DNA damage gains importance as a pre-cancerous biomarker.Methods-The alkaline Single Cell Gel Electrophoresis assay was carried out in peripheral blood leukocytes of obese-CVD patients (n=28; 14 males and 14 females) and matched controls (n=13; 7 males and 6 females). Multiple regression and analysis of variance were performed for effect of confounding/specific factors on DNA damage and the Student’s t-lest to compare differential values for factors associated with obesity-CVD and DNA damage.Results-In patients, genomic damage was significantly higher (p
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