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Detection of IL-4, IL-6 and IL-12 Serum Levels in Generalized Aggressive Periodontitis

Author(s): Maryam Robati | Ardeshir Ranjbari | Mehri Ghafourian Boroujerdnia | Zahra Chinipardaz

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 3;
Start page: 170;
Date: 2011;
Original page

Keywords: Aggressive Periodontitis | IL-4 | IL-6 | IL-12 | Serum

Background: Periodontitis is a multifactorial chronic inflammatory diseasecharacterized by destruction of tooth-supporting tissues. Environmental and geneticfactors as well as the immune system participate in this process. Recent studies haveattempted to elucidate the role of cytokine networks involved in periodontal diseases.Objective: To assess and compare the levels of IL-4, IL-6 and IL-12 in serum samplesof patients with generalized aggressive periodontitis (GAgP) and control individuals.Methods: A total of 50 subjects were included in the study of which 25 patients hadgeneralized aggressive periodontitis and 25 were healthy unrelated age and gendermatched patients undergoing extraction and surgical crown lengthening (control group).Local blood samples of patients were collected from surgical sites of pocket reductionand from healthy individuals before tooth extraction or crown lengthening from noninflamed sites. The levels of IL-4, IL-6 and IL-12 were determined by an ELISA assayusing serum samples separated from the whole blood of both groups. Results: The levelof IL-4 increased significantly in control group in comparison with the test group(p=0.002). The amount of IL-6 in GAgP patients increased strongly compared withcontrol group (p
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