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Detection of Leptospires serogroups, Which Are Common Causes of Human Acute Leptospirosis in Guilan, Northern Iran

Author(s): HR Honarmand | SS Eshraghi

Journal: Iranian Journal of Public Health
ISSN 2251-6085

Volume: 40;
Issue: 1;
Start page: 107;
Date: 2011;
Original page

Keywords: Serogroups | Leptospirosis | IgM-ELISA | Microscopic agglutination test

"nBackground: This study is performed to reveal most common species and subspecies of leptospires that are main causes of hu­man leptospirosis in Guilan, Northern Province of Iran. "nMethods: We performed IgM-ELISA and MAT on 282 blood samples from patients who attended to 3 hospitals in the flat area of Guilan Province with clinical symptoms consisted with leptospirosis.  All specimens with titers ≥ 160 against at least one pathogenic strain in MAT and with titers ≥160 in IgM-ELISA were regarded confirmed positive cases indicative acute dis­ease. For any confirmed positive cases, we determined the strains, which had the highest titer to determine the frequency of most common serovars and serogroups. "nResults: Seventy of 282 sera had titers ≥160 against at least one pathogenic strain in MAT and titers ≥ 160 in IgM-ELISA. We determined frequency of common causative serogroups which had highest titers in 70 positive cases and only cases which had high titers in MAT and in IgM-ELISA were selected which is a reliable criterion to detect acute disease and to deter­mine causative serogroup."nConclusion: Nine serogroups including sejroe, grippotyphosa, mini, ictero haemorrhagiae, celledoni, autumnalis, cynopteri, pomona, and javanica were more responsible of acute leptospirosis in Guilan.
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