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Determinação de resíduos de cloranfenicol em amostras de leite e mel industrializados utilizando a técnica de espectrometria de massas em "tandem" (CLAE-EM/EM)

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Author(s): Martins Júnior Helio Alves | Bustillos Oscar Vega | Pires Maria Aparecida Faustino | Lebre Daniel Temponi | Wang Alexandre Yautin

Journal: Química Nova
ISSN 0100-4042

Volume: 29;
Issue: 3;
Start page: 586;
Date: 2006;
Original page

Keywords: chloramphenicol | milk | honey

ABSTRACT
The present work shows a method for the determination of chloramphenicol (CAP) antibiotic in milk, powder milk and honey. The solid phase extraction and liquid-liquid extraction were applied as a clean-up and pre-concentration strategies followed by LC-ESI/MS/MS analysis. The recovery was studied for different fortification levels from 0.05 to 1.00 µg L-1 in milk, showing values between 91 101% and RSD bellow 8.0%, while honey was spiked with a concentration of 0.20 µg kg-1 yelding a mean recovery of 83% and RSD of 6.5%. The quantification transition 321>152 showed a LOD of 0.52 ng kg-1 and LOQ of 1.85 ng kg-1.
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