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DETERMINATION OF ANTIULCER ACTIVITY OF PLUMERIA RUBRA LEAVES EXTRACTS

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Author(s): Misra Vimlesh | Yadav Garima | Uddin Sheikh Mubeen | Srivastava Vivek

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 194;
Date: 2012;
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Keywords: Plumeria rubra | Ulcer | Pylorus ligation | Ethanol induced ulcer.

ABSTRACT
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Here, present study was carried out to investigate antiulcer activity of ethanol (EEPR) and chloroform (CEPR) extract of P. rubra L. (Family: Apocynaceae) leaves in pylorus ligated and ethanol induced ulceration in the albino rats. 250 mg/kg of both ethanol and chloroform extracts were selected for the Pharmacological study. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, protein assay, mucin assay, antioxidant estimation and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for ethanol induced ulcer model. The results suggest that the ethanol and chloroform extract of P. rubra posses the significant antiulcer activity.
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