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Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats

Author(s): Srivastava Vivek | Viswanathaswamy A.H.M | Mohan Govind

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 42;
Issue: 3;
Start page: 185;
Date: 2010;
Original page

Keywords: Antiulcer activity | pyloric ligation model | sodium cromoglycate | ulcer index

Objectives : To study the ulcer protective property of sodium cromoglycate in pylorus-ligated rats and the biochemical role in ulcer protection by various biochemical tests. Materials and Methods : The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined. Results : Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control. Conclusion : Sodium cromoglycate has activity equipotent to ranitidine.
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