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Determination of beta-endorphin plasma concentrations in surgical patients with acute abdominal pain

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Author(s): Popović Nada | Kojić Zvezdana Ž. | Bumbaširević Vladimir Ž. | Pavlović A. | Stefanović Branislav | Karamarković Aleksandar P. | Radenković Dejan | Nikolić V.

Journal: Acta Chirurgica Iugoslavica
ISSN 0354-950X

Volume: 51;
Issue: 3;
Start page: 51;
Date: 2004;
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Keywords: beta-endorphin | abdominal surgery | pain | stress

ABSTRACT
Abdominal pain and surgery, frequently associated with this kind of pain, modify plasma levels of stress-hormones and initiates the response of endogenous analgesics system. The aim of this study was to determine serum concentration of beta-endorphine in patients with acute abdominal pain (n=12), which were surgically treated. Serum concentration of beta-endorphin was measured on five data points: before, during and after surgery. During abdominal surgery serum concentration of beta-endorphin was increased by 7% compared to preoperative period; in postoperative period the concentration continued to rise and remained increased within next hours. The maximal levels of beta-endorphine were not observed during, and immediately after surgery. Postoperatively, between 6 and 8 p.m. on the day of surgery, maximal level of beta-endorphin was noted, which was even ten times higher than to preoperative value. Plasma level of beta-endorphin fell to the baseline values 24 hours after surgery. In conclusion, abdominal surgery induces a postponed (delayed) increase in serum beta-endorphine levels, which are associated with modulation of preoperative, intraoperative and postoperative pain perception.
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