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DETERMINATION OF THE CONCENTRATION BLENDS OF SUPERDISINTEGRANT FOR FAST DISINTEGRATING TABLETS

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Author(s): Nitesh Sharma et al.

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 2;
Issue: 11;
Start page: 2828;
Date: 2011;
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Keywords: Superdisintegrant | Fast disintegrating tablet | Croscarmellose | Crosspovidone | Sodium Starch Glycolate | Paracetamol

ABSTRACT
In this research work, different blends of superdisintegrants with different ratio in fixed concentration were taken and placebo tablets were formulated and evaluated with a view to optimize a formula and concentration blends of superdisintegrants for Fast Disintegrating Tablets (FDT). In this research work three superdisintegrants, viz. Crosscarmellose, Crospovidone and Sodium Starch Glycolate were used in different ratio (1:1, 1:2, 2:1) in fixed concentration of 4% w/w in combination in each batch. Six blends were prepared and 3 batches of tablets of each formulation code blend were formulated and evaluated for pre-compression parameters like Compressibility, Hausner’s ratio, Bulk density, Tapped density and post-compression parameters like Hardness, Weight variation, Disintegration time, Dispersion time, Friability, Wetting time, Water absorption ratio. Based on results it revealed that the formulation code blend A3 which had Croscarmellose, Crosspovidone in ratio 1:2 (4%w/w) emerged as best blend of superdisintegrants for FDT formulation. To optimize the formula of A3 blend, Paracetamol FDT was formulated and evaluated using the concentration blend of A3; three batches were formulated and evaluated for all above parameters and in-vitro drug release (pH5.8 phosphate buffer) and disintegration time was found between 23-27 seconds and release was more than 80% in 30 minute. We can conclude that a good FDT can be formulated using the above A3 blend concentration.
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