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Determination of Hepatitis C Genotypes and the Viral Titer Distribution in Children and Adolescents with Major Thalassemia

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Author(s): Touran Shahraki | Mansour Shahraki | Esmaiel Sanei Moghaddam | Mehri Najafi | Ali Bahari

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 20;
Issue: 1;
Start page: 75;
Date: 2010;
Original page

Keywords: Hepatitis C | Virus Titer | Viral Load | Liver Function Tests | Thalassemia | Iran

ABSTRACT
Objective: Hepatitis C virus (HCV) is an etiological agent responsible for occurrence of post-transfusion hepatitis in thalassemic patients. This study identified hepatitis C genotypes in pediatric and adolescent thalassemic patients and their correlation with age, blood transfusion, HCV RNA viral titer and liver function. Methods: This study considers cross-sectional data from the Center for Thalassemia in Zahedan (Iran) carried out between August 2005 and September 2007. Twenty multitransfused patients suffering from β-thalassemia major and chronic HCV infection (13 males, 7 females) were included in the study. Patients were considered eligible for the study if they were seropositive for HCV RNA polymerase chain reaction (PCR) before initiation of evaluation. Blood sample was taken for HCV genotype and viral titer as well as biochemical markers. Type specific primer and real-time RT-PCR HCV were used for determination of viral genotype and HCV-RNA titer. Findings: There was a significant positive correlation between serum HCV RNA titer and genotypes (P
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