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Determination of Nephrotoxicity and Hepatoxicity of Monosodium Glutamate (MSG) Consumption

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Author(s): H.M. Inuwa | V.O. Aina | Baba Gabi | I. Aim ola | Leehman Ja’afaru

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 3;
Start page: 148;
Date: 2011;
Original page

Keywords: Adult wister rats | hepatoxicity | monosodium glutamate | nephrotoxicity | serum biochemistry carcinogenic

ABSTRACT
Investigations were conducted to determine the Nephrotoxicity and Hepatoxicity of Monosodium Glutamata (MSG). Graded doses of monosodium glutamate were administered orally to Adult Wister rats weighing between (160.7-238.6 g) for 28 days. Liver and Kidney function tests were carried out on the blood serum. Monosodium glutamate elicited an increase in body weight in an ascending fashion from group B to group D though not statistically significant (p>0.05) Biochemical parameters (Electrolytes, Urea, Creatinine, RBC, Cholesterol and Enzymes) were not seriously affected though there were increases in the concentration or levels of same of them. This shows that monosodium glutamate has hepatoxicity and nephrotoxicity tendencies especially when consumed at higher concentrations.
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