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Determination of plasma gluthatione reductase enzyme activity in osteoporotic women

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Author(s): Sadeghi N. | Oveisi M.R. | Jannat B. | Hajimahmoodi M. | Jamshidi A.R. | Sajadian Z.

Journal: DARU : Journal of Pharmaceutical Sciences
ISSN 1560-8115

Volume: 16;
Issue: 1;
Start page: 51;
Date: 2008;
Original page

Keywords: Glutathione reductase

ABSTRACT
Background: Osteoporosis is a disease of high prevalence with increased bone loss. Free radicals have been proved to be involved in bone resorption. Glutathione reductase (GR) plays an essential role in cell defense against reactive oxygen metabolites by sustaining the reduced status of an important antioxidant, glutathione. In the present study GR activity of plasma as an antioxidant enzyme in relation to Bone Mineral Density (BMD) was investigated.Material and Method: GR activity was measured spectrophotometrically at 339 nm in 138 women. Participants were selected by inclusion and exclusion criteria from those who were referred to Jamie Clinic in Tehran for BMD evaluation.Results: Plasma activity of GR (Mean± SD) was: 64.44 ± 37.68 U/L in the control group, 75.49 ± 54.84 U/L in the total patients [(mild Osteopenia + severe Osteopenia and Osteoporosis) (Tscore
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