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TO DEVELOP UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF SILDENAFIL CITRATE IN BULK AND TABLET

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Author(s): Ashok Kumar

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 7;
Start page: 12;
Date: 2010;
Original page

Keywords: Sildenafil citrate | UV spectroscopy | Estimation | Tablets.

ABSTRACT
A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of Sildenafil citrate in bulk and tablet dosage form. Solution of sildenafil citrate in methanol shows maximum absorbance at 291 nm. Beer’s law was obeyed in the concentration range of 5-30 µg mL-1 correlation coefficients, detection and quantitation limits were also calculated. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablets dosage forms. Result of percentage recovery and placebo interference showed that the method was not affected by the presence of common excipients. The percentages assay of sildenafil citrate in tablet was 100 mg of 99.87% and 50 mg of 99.84%. The method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of Sildenafil in bulk and tablets.
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