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Development, characterization and evaluation of microemulsion gel for transdermal delivery of furosemide.

Author(s): Surjyanarayan Mandal*, Snigdha S. Mandal, Rajesh K.S

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3133;
Date: 2011;
Original page

Keywords: Microemulsion | Furosemide | Globule size | Transdermal delivery | Pseudo ternary Phase Diagram.

The aim of the present study was to develop, characterize and evaluate novel o/w microemulsion gel for transdermal delivery of Furosemide. Oil and surfactant wereselected based on their drug solubilizing capacity, biocompatibility and HLB value. Pseudoternary phase diagrams were developed at different ratios ofsurfactant and cosurfactant to optimize their ratio. Furosemide loaded microemulsion using Isopropyl Myristate, Tween-60 and n-Butanol as oil, surfactantand cosurfactant respectively, was prepared by water titration method, its gel was developed using Carbopol P-934 and was characterized. Toxicity study wascarried out in excised rat skin. Stability study of both the formulations was carried out for 6 months. The developed formulation was found to be optically clearand stable with globule size leas than 25nm and zeta potential -12.7 mV ± 0.2 respectively. Dilution study showed that the formulation was compatible withexcess of water. In vitro skin permeation study revealed that after 10 hrs, more than 30% of the drug was permeated through the excised skin from themicroemulsion system, as compared to its gel form, however more sustained release was observed for microemulsion gel. Results revealed that developedformulation could appear to be an effective transdermal delivery system of water insoluble drug with safe and enhanced skin permeability.

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