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DEVELOPMENT AND EVALUATION OF ACECLOFENAC TRANSDERMAL PATCHES USING HYDROPHILIC AND HYDROPHOBIC POLYMERS

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Author(s): M. S. Shankar

Journal: Journal of Global Pharma Technology
ISSN 0975-8542

Volume: 2;
Issue: 4;
Date: 2010;
Original page

Keywords: Aceclofenac | transdermal patches | inhibition | in vitro skin permeation study

ABSTRACT
 In this study, matrix-type transdermal patches containing Aceclofenac were prepared using different ratios of polyvinylpyrrolidone (PVP) and ethylcellulose (EC) by solvent evaporation technique using 10%w/w of dibutyl phthalate incorporated as plasticizer. The drug matrix film of PVP and EC was casted on a polyvinylalcohol backing membrane that was previously dried at 600C for 6 hrs. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, Tensile strength, flatness and Drug content determination), in vitro release studies and in vitro skin permeation studies. The physiochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility.  In vitro permeation studies were performed across cadaver skin using a Franz diffusion cell. Variations in drug release profiles among the formulations studied were observed. Based on a physicochemical and in vitro skin permeation study, formulation F1 (PVP/EC, 5:1) and F5 (PVP/EC, 1:5) were chosen for further in vivo experiments. The anti-inflammatory effect and a sustaining action of Aceclofenac from the two transdermal patches selected were studied by inducing paw edema in rats with 1% w/v carrageenan solution. When the patches were applied half an hour before the sub plantar injection of carrageenan in the hind paw of male Wistar rats, it was observed that formulation F1 produced 91.04% inhibition of paw edema in rats 10hrs after carrageenan insult, whereas in the case of formulation F5, the value became 43.34% at 10 hrs after the carrageenan insult. Hence, it can be reasonably concluded that Aceclofenac can be formulated into the transdermal matrix type patches to sustain its release characteristics.
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