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Development and evaluation of mucoadhesive microspheres of pioglitazone maleate

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Author(s): Ram Chand Dhakar1,Sheo Datta Maurya1 ,Bhanu P S Sagar1 , Anish K Gupta2 ,Ghanshyam Maurya3

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 2;
Start page: 456;
Date: 2011;
Original page

Keywords: Microspheres | Diabetes type-2 | Mucoadhesion | Controlled Drug Release | Sodium CMC | Carbopol 934P | Sodium Alginate

ABSTRACT
The present work was envisaged to formulate and systematically evaluate In vitro performances of mucoadhesive microspheres of Pioglitazone maleate for treatment of diabetes type-2, which have the ability to reside in the gastrointestinal tract for an extended period and can be utilized for controlled release of Pioglitazone maleate in oral administrations. Microspheres were prepared by emulsification solvent evaporation method using Sodium CMC, Carbopol 934P, and sodium alginate as a mucoadhesive polymers. Microspheres prepared were found discrete, spherical and free flowing. They ranged in particle size from 21 to 37 μm. The microspheres exhibits good mucoadhesive properties and showed high drug entrapment efficiency. Pioglitazone maleate release from these microspheres was slow and extended and dependent on the type of polymer used. Formulations F1 containing Sod. CMC showed the maximum release 91.45% after 10 hrs. Among all the formulation, formulation F1 containing Sod. CMC and F2 containing Carbopol 934P showed the best reproducible results and the mucoadhesive profile with good surface morphology. The work has demonstrated that microspheres, particularly those of Sod. CMC are promising candidate for the sustained release of Pioglitazone maleate in the gastrointestinal tract.
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