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DEVELOPMENT AND EVALUATION OF ZERO ORDER SUSTAINED RELEASE MATRIX TYPE TRANSDERMAL FILMS OF IBUPROFEN

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Author(s): Vidyavati Sankavarapu | Jithan Aukunuru

Journal: Journal of Global Pharma Technology
ISSN 0975-8542

Volume: 2;
Issue: 2;
Date: 2010;
Original page

Keywords: Transdermal film | Ibuprofen | Sustained release | Matrix | Polymer

ABSTRACT
The purpose of this work was to develop a zero order drug release matrix type transdermal drug delivery system with ethyl cellulose as the matrix polymer. Different solvents were used for casting the films and evaluated for their mechanical properties and In vitro drug release pattern. Ethyl cellulose dual transdermal films of ibuprofen were prepared by solvent evaporation method. The films were matrix type in which one thin film included the drug in free form and the other film was loaded with biodegradable polycaprolactone microspheres. Both the patches were attached with polyvinylpyrrolidone solution (10% w/v in ethanol) as an adhesive. The thin free drug film was transparent, tacky and highly flexible whereas, microspheres loaded film was translucent, non-tacky and less flexible. Ibuprofen release from this dual film followed zero order drug release with a sustained effect for 24hrs. Burst effect was seen when the free film was faced towards the receptor compartment of the Franz diffusion cell however, the microsphere loaded film facing towards receptor compartment showed appropriate zero order drug release pattern.
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