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Development of fast dissolving Nimodipine tablets: effect of functionality of Superdisintegrants

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Author(s): N. G. Raghavendra Rao*, Md. Subhan

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2957;
Date: 2011;
Original page

Keywords: Fast dissolving tablet | Nimodipine | croscarmellose sodium | sodium starch glycolate | crospovidone | Kyron T-314 | Disintegration time.

ABSTRACT
Nimodipine is an antihypertensive, calcium channel blocker, vasodilator agent and used in the treatment of various cardiovascular disorders such as angina pectoris,cardiac arrhythmia and hypertension. Oral bioavailability of nimodipine is around 13% and having half life 9 hrs. In present research work an attempt has beenmade to prepare fast dissolving tablets of nimodipine by direct compression method using Sodium starch glycolate, croscarmellose sodium, Kyron T-314 andcrospovidone as a superdisintegrants. Effects of superdisintegrants on wetting time, disintegrating time, drug content, in-vitro release, and stability studiesparameters have been studied. The prepared tablets were characterized by DSC and FTIR Studies. No chemical interaction between drug and excipients wasconfirmed by DSC and FTIR studies. The blend was examined for the pre-compressional parameters. The prepared tablets formulations were evaluated for postcompressionalparameters. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All thepost-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The disintegration time of 11 to 28 sec, waterabsorption ratio of 70.23 to 88.93%, wetting time of 13 to 47 sec, and in-vitro drug release showed 70.47 - 99.90% within 9 min. The drug release from FDTsincreased with increasing concentration of superdisintegrants and was found to be highest with formulations containing crospovidone. The stability study conductedas per the ICH guidelines and the formulations were found to be stable. The results concluded that fast dissolving tablets nimodipine showing enhanced dissolution,will lead to improved bioavailability, improved effectiveness and hence better patient compliance.
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