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DEVELOPMENT OF MELOXICAM SODIUM TRANSDERMAL GEL

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Author(s): Dr. Shashikant D. Barhate

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 5;
Start page: 11;
Date: 2010;
Original page

Keywords: Meloxicam Sodium | Carbapol 934P | Box-Behaken design

ABSTRACT
High molecular weight water soluble homopolymer of carbapol 934P resins are reported to possess very high viscosity in low concentration, transparency and film forming properties useful for gels. The meloxicam sodium gels were prepared by varying the concentration of penetration enhancer’s ethanol, PEG 400, menthol and azone. Selection of optimized batch was done on the basis of results of rheological studies and in-vitro drug permeation. Formulation F19 with highest amount of menthol shows highest permeability of meloxicam sodium (89.96%) at the end of 12 hrs this indicates that menthol showed significant permeation enhancement effect. The permeation rate (flux) for F19 was 260.11 µg/cm2/h. Obtained R2 values for zero-order model suggests that the drug follows zero-order release kinetics. The rheological characterization of formulated systems showed that the systems exhibit non-Newtonian behavior and The optimized formulation C1 showed higher % cumulative permeation of meloxicam sodium (> 95.00%) and permeation rates (flux).

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