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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF NAPROXEN AND PANTOPRAZOLE IN PHARMACEUTICAL DOSAGE FORM

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Author(s): Rajnish Kumar

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 12;
Start page: 23;
Date: 2011;
Original page

Keywords: Naproxen | Pantoprazole | HPLC

ABSTRACT
A simple, sensitive, and precise high performance liquid chromatographic method for the analysis of naproxen and pantoprazole has been developed, validated and used for the determination of compounds in commercial pharmaceutical products. The compounds were well separated on a Hypersil BDS C-18 reversed-phase column by use of a mobile phase consisting of 0.1 M sodium acetate (pH 8.2), acetonitrile and methanol (70:20:10 v/v) at a flow rate of 1.0 mL min-1 with detection wavelength at 285 nm. The linearity ranges were 5-70 µg mL-1 for naproxen, and 5-40 µgmL-1 for pantoprazole. The recovery amount was more than 99 %. The high recovery and low relative standard deviation confirms the suitability of the method for determination of naproxen and pantoprazole in pharmaceutical dosage forms.
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