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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF METRONIDAZOLE IN TABLET FORMULATION

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Author(s): Arun K. Mishra

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 6;
Start page: 4;
Date: 2010;
Original page

Keywords: Metronidazole (MND) | UV determination | Tablet dosage form

ABSTRACT
The present research work discusses the development of a UV spectrophotometric method for Metronidazole. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Metronidazole (MND) in Tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (? max) was found to be 277nm. The percentage recovery of Metronidazole was in the 98.2±0.129. Beers law was obeyed in the concentration range of 1-10µg/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.0283x+0.0407 with r2 of 0.9902 was obtained. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of MND in tablet formulation for quality control purposes.
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