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Development and Validation of UV Spectrophotometric Method for the Estimation of Tolvaptan in Bulk and Tablet Dosage Form

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Author(s): Bharatkumar Ganeshbhai Chaudhari | Chintu Patel

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 3;
Start page: 193;
Date: 2012;
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Keywords: Spectrophotometry | Tolvaptan | Validation

ABSTRACT
A simple, rapid, accurate and precise assay procedure based on Spectrophotometric method has been developed for the estimation of Tolvaptan in Pharmaceutical formulation. The method was based on estimation of Tolvaptan at absorption maxiam about 274 nm using methanol as adiluent. The proposed method was linear over the range of 2-20 μg/mL with correlation co-efficient (r2) of 0.998 and mean recovery for tolvaptan was 99.61 %. The intermediate data obtained under different experimental setup, the calculated value of co-efficient of variance (CV, %) was found to be within a limit. The proposed method can be successfully applied for the analysis of Tablet formulation.
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