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Development and validation of UV spectroscopy method for estimation of lacosamide in bulk and formulations

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Author(s): Ganji Ramanaiah | D. Ramachandran | G.Srinivas | Srilakshmi | Purnachanda Rao

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 03;
Issue: 01;
Start page: 10;
Date: 2012;
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Keywords: Lacosamide | UV-Visible spectroscopy | Validation | Dosage form

ABSTRACT
A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of Lacosamide in bulk and its pharmaceutical formulation. The method was validated as per International Conference on Harmonization [ICH] guidelines. The Lacosamide was monitored at 230 nm with UV detection and there is no interference of diluent at 230 nm for lacosamide. The method was linear (r2=0.999) at concentration ranging from 12 to 40 μg/mL, precise (intra and inter-day RSD values < 1.0%), accurate (mean recovery = 99.9%), specific and robust. The results showed that the proposed method is suitable for the precise, accurate and rapid determination of lacosamide in bulk and tablet dosage forms.

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