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DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF AMOXYCILLIN TRIHYDRATE IN PHARMACEUTICAL DOSAGE FORM

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Author(s): Patel Satish A | Patel Natavarlal J.

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 48;
Date: 2011;
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Keywords: Amoxycillin trihydrate | Chromogen | Ninhydrin reagent | Visible spectrophotometric | Tablet.

ABSTRACT
A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of amoxycillin trihydrate in tablets. The method is based on the reaction of amoxycillin trihydrate with ninhydrin reagent in methanol giving blue color chromogen, which shows maximum absorbance at 578 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 10-80 µg/ml for amoxycillin trihydrate. The results of the analysis have been validated statistically and by recovery studies.
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