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DEVELOPMENT AND IN VITRO EVALUATION OF CHITOSAN GEL FOR WOUND HEALING ACTIVITY

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Author(s): Shinde Anilkumar J. | Khade Kishorkumar M | Kadam Atul R. | More Harinath N

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 271;
Date: 2011;
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Keywords: Chitosan | gel | wound healing | wound closure | Dead space wound.

ABSTRACT
The present study aims to evaluate the wound healing activity of gel containing chitosan in rats. Chitosan is reported for wound healing activity, four optimized gel formulations were prepared, out of that CG-4 showed promising physical properties like colour, pH, consistancy, spreadability, extrudability as that of marketed wound healing cream formulations. Topical application of the test formulation CG-4 gel formulation was used for treatment group, which has showed significant wound healing activity in excision wound model. Percentage wound closure, period of complete epithelisation and scar size reduction on complete epithelisation showed P value
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