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Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children

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Author(s): Bruck Isac | Tahan Tony Tannous | Cruz Cristina Rodrigues da | Martins Luzilma Terezinha Flenik | Antoniuk Sérgio Antonio | Rodrigues Marcelo | Souza Sílvia Mara de | Bruyn Laís Regina de

Journal: Arquivos de Neuro-Psiquiatria
ISSN 0004-282X

Volume: 59;
Issue: 3B;
Start page: 691;
Date: 2001;
Original page

Keywords: human immunodeficiency virus (HIV) | neurodevelopment delay | neurological screening test

ABSTRACT
The aim of the study was to detect neurological abnormalities in human immunodeficiency virus (HIV) infected children. This was achieved by a prospective evaluation, from November/1995 to April/2000, of 43 HIV infected children (group I) and 40 HIV seroreverters children (group II) through neurological exam and neurodevelopmental tests: Denver Developmental Screening Test (DDST) and Clinical Adaptive Test / Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS). A control group (III), of 67 children, were evaluated by CAT/CLAMS. Hyperactivity, irritability and hypotonia were the findings on neurological examination, without statistical differences between group I and II. On CAT/CLAMS, the group I developmental quotient (DQ) was significantly lower than the other groups. The same occurred in DDST, with group I presenting significantly more failures than group II. Nineteen HIV children of group I had brain computed tomographic scan, with abnormalities in three of them (basal ganglia calcification, white matter hypodensity and asymmetry of lateral ventricles). We conclude that in HIV infected children a neurodevelopment delay occur early in the disease, and it can be detected by screening tests.
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