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Developmental toxic effects in suckling pups of rats from dams treated with diclofenac

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Author(s): M. K. Shindala | L. E. Shemiss

Journal: Iraqi Journal of Veterinary Sciences
ISSN 1607-3894

Volume: 24 (Arabic);
Issue: 2;
Start page: 155;
Date: 2010;
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ABSTRACT
The aim of the present study was to assess developmental toxic effects in suckling pups of rats from dams treated withdiclofenac (0.5, 2.5, 5, 15, 30, 60 mg/kg, i.m.) given once daily for 10 consecutive days (first nursing period). Exposure ofsuckling offspring to diclofinac through the milk caused severe toxic effects in pups which appeared as high mortality rate inpups from dams treated with diclofenac at (15, 30, 60 mg/kg) manifested by sharply reduced in the percentage of survival ofthe pups to weaning to (0%). In addition, the pups from dams treated with diclofenac (2.5 mg/kg) demonstrated retardation insomatic growth which appearred as significantly decreased body weight rate and index of development accompanied by asignificantly increased in the liver / body weight ratio of pups. In conclusion, the results suggest that diclofenac induceddevelopmental toxic effects in suckling pups of rats exposed to its through the milk.

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