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Diagnostic and Prognostic Value of Serum Albumin for Tuberculosis in HIV Infected Patients Eligible for Antiretroviral Therapy: Data from an HIV Cohort Study in India

Author(s): Gerardo Alvarez-Uria | Manoranjan Midde | Raghavakalyan Pakam | Praveen Kumar Naik

Journal: BioImpacts
ISSN 2228-5652

Volume: 3;
Issue: 3;
Start page: 123;
Date: 2013;
Original page

Keywords: Developing Countries | Hypoalbuminemia | India | Public Health | Mortality | Cost Savings

Introduction: Tuberculosis is difficult to diagnose and it is the leading cause of death in HIV infected individuals in developing countries. There is an urgent need of low-cost diagnostic markers for resource-limited settings. Methods: The study involved 1571 patients from an HIV cohort study in India with known serum albumin concentrations at the time of becoming eligible for antiretroviral therapy (ART). We investigated the diagnostic accuracy of serum albumin to predict tuberculosis within six months of ART eligibility and the prognostic value in patients who experienced tuberculosis. Results: The diagnostic accuracy of serum albumin, measured by the area under the receiver operating characteristic curve, to predict tuberculosis was 0.81 (95% confidence interval 0.78-0.83). Serum albumin concentrations
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