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Diagnostic Significance of Combining Telomerase Activity with CYFRA21-1 Level in Differentiating Malignant Pleural Effusion Caused by Lung Cancer from Benign Pleural Effusio

Author(s): Hongmei LI | Junhua FU | Yuande XIU | Qinghua ZHOU

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 13;
Issue: 6;
Start page: 652;
Date: 2010;
Original page

Keywords: Telomerase | CYFRA21-1 | Pleural effusion | Differential diagnosis

Background and objective Telomerase and CYFRA21-1 may be positively expressed in malignant pleural effusion, but the sensitivity and specificity of single tumor marker were low. The aim of this study is to investigate the diagnostic value of combining determination of telomerase activity and CYFRA21-1 levels in differentiating benign from malignant pleural effusion caused by lung cancer. Methods 80 patients with malignant and 50 patients with benign pleural effusion were enrolled into this study. The telomerase activity in pleural effusion was tested by means of telomeric repeat amplification protocal-PCR-ELISA (TRAP-PCR-ELISA) and CYFRA21-1 levels were tested by the EIA method. All the results were analyzed by the statistical method. Results The levels of telomerase and CYFRA21-1 in malignant pleural effusion was significantly higher than that in benign one (t =17.252 and t =13.951, P
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