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Diagnostic value of 18F-FDG PET/CT for cancer pain of peripheral nerves

Author(s): Lei FANG | Jian-ping AN | Hui ZHAO | Xiao-hong XU | Jun-feng MAO | Yun LI | Wei DAI

Journal: Medical Journal of Chinese People's Liberation Army
ISSN 0577-7402

Volume: 38;
Issue: 11;
Start page: 909;
Date: 2013;
Original page

Keywords: neoplasm metastasis | neuropathic pain | tomography | X-ray computed | positron-emission tomography | fluorodeoxyglucose F18

Objective To observe the characteristics of cancer pain of the peripheral nerves on 18F-FDG PET/CT images, and explore the diagnostic value of 18F-FDG PET/CT for cancer pain of the peripheral nerves. Methods Imaging data of 18F-FDG PET/CT of 10 patients with cancer pain of the peripheral nerves confirmed by histopathology or long-term follow-up were analyzed retrospectively. The similarities and differences in PET/CT manifestations between the diseased side peripheral nerves and contralateral normal peripheral nerves were observed, and the maximum standardized uptake values (SUVmax) were compared by paired t test with SPSS 17.0 software. Results Seventeen secondary malignant peripheral nerve lesions were found in 10 cases. On PET images, the lesions were found to spread along the plexus, nerve bundle or intervertebral foramen, and manifested as bundle-, root-hair- or nodule-like high 18F-FDG metabolic tissue, with the SUVmax as high as 6.67±3.24. The lesions on CT images manifested as bundle-, root-hair- or nodule-like soft tissue density shadows spreading along the nerve bundle or nerve root canal, and there was no clear border between the lesions and the surrounding soft and fat tissues. The contralateral normal peripheral nerves showed no abnormal images on 18F-FDG PET or CT, and the SUVmax was 1.19±0.48, which was significantly different from that of nerves on disease side (t=9.389, P

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