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Diagnostic value of eosinophil cationic protein in children with asthma undergoing food challenges --- Znaczenie eozynofilowego bialka kationowegoU dzieci chorych na astme, poddanych Prowokacjom alergenami pokarmowymi

Author(s): Aneta Krogulska | Jaroslaw Dynowski | Krystyna Wssowska-Krolikowska

Journal: Przegląd Pediatryczny
ISSN 0137-723X

Volume: 37;
Issue: 2;
Start page: 170;
Date: 2007;
Original page

Rationale: The role of food allergens in children with asthma has not been completely elucidated and interpretation of food challenges outcomes is occasionally difficult. Therefore, we decided to evaluate serum ECP level during food challenges. Material and methods: Sixteen patients with asthma and IgE-dependent food allergy underwent double blind placebo controlled food challenges in connection with methacholin inhalation test. Blood samples for ECP were collected before, 4 hours and 24 hours after the challenge. ECP was quantified by ImmunoCAP (Pharmacia-Upjohn, Sweden). Results: The median ECP level in patients before the challenge tests was 15.7+/-9.7 ug/1 and was significantly higher in children with concomitant atopic egzema - 23.1+/-8.02 ug/1 and non significantly higher in children with increased bronchial reactivity - 19.8+/-10.08 ug/1. Four hours after the allergen or placebo challenge, the median ECP did not change significantly, but after 24 hours it increased after the allergen challenge, but not after the placebo challenge (p
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