Author(s): Aneta Krogulska | Jaroslaw Dynowski | Krystyna Wssowska-Krolikowska
Journal: Przegląd Pediatryczny
ISSN 0137-723X
Volume: 37;
Issue: 2;
Start page: 170;
Date: 2007;
Original page
ABSTRACT
Rationale: The role of food allergens in children with asthma has not been completely elucidated and interpretation of food challenges outcomes is occasionally difficult. Therefore, we decided to evaluate serum ECP level during food challenges. Material and methods: Sixteen patients with asthma and IgE-dependent food allergy underwent double blind placebo controlled food challenges in connection with methacholin inhalation test. Blood samples for ECP were collected before, 4 hours and 24 hours after the challenge. ECP was quantified by ImmunoCAP (Pharmacia-Upjohn, Sweden). Results: The median ECP level in patients before the challenge tests was 15.7+/-9.7 ug/1 and was significantly higher in children with concomitant atopic egzema - 23.1+/-8.02 ug/1 and non significantly higher in children with increased bronchial reactivity - 19.8+/-10.08 ug/1. Four hours after the allergen or placebo challenge, the median ECP did not change significantly, but after 24 hours it increased after the allergen challenge, but not after the placebo challenge (p
Journal: Przegląd Pediatryczny
ISSN 0137-723X
Volume: 37;
Issue: 2;
Start page: 170;
Date: 2007;
Original page
ABSTRACT
Rationale: The role of food allergens in children with asthma has not been completely elucidated and interpretation of food challenges outcomes is occasionally difficult. Therefore, we decided to evaluate serum ECP level during food challenges. Material and methods: Sixteen patients with asthma and IgE-dependent food allergy underwent double blind placebo controlled food challenges in connection with methacholin inhalation test. Blood samples for ECP were collected before, 4 hours and 24 hours after the challenge. ECP was quantified by ImmunoCAP (Pharmacia-Upjohn, Sweden). Results: The median ECP level in patients before the challenge tests was 15.7+/-9.7 ug/1 and was significantly higher in children with concomitant atopic egzema - 23.1+/-8.02 ug/1 and non significantly higher in children with increased bronchial reactivity - 19.8+/-10.08 ug/1. Four hours after the allergen or placebo challenge, the median ECP did not change significantly, but after 24 hours it increased after the allergen challenge, but not after the placebo challenge (p