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Diagnostic value of urinary pyridinoline for determining bone metastasis in patients with non-metastatic breast cancer

Author(s): Zeynep Giniş | Sevilay Sezer | Nuriye Özdemir | Fatma Uçar | Serpil Turhan

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 4;
Start page: 420;
Date: 2011;
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Keywords: Breast neoplasms | bone metastases | deoxypyridinoline | pyridinoline

Objective: In this study, urinary pyridinoline (uPYR), urinary deoxypyridinoline (uDPD) and serum alkaline phosphatase (sALP) levels were measured in patients without metastatic breast cancer and the role of uPYR and uDPD as biochemical markers of bone metastases were examined during a six years follow-up.Materials and methods: Totally, 34 patients without bone metastasis and 40 healthy individuals as a control group were included in the study.Results: Urinary pyridinoline and uDPD levels were significantly higher in patients without bone metastasis than in normal controls (p
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