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Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats

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Author(s): Majid Rahgozar | Hamid Reza Pazoki Toroudi | Azam Bakhtiarian | Bijan Djahanguiri

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 1;
Issue: 1;
Start page: 5;
Date: 2002;
Original page

Keywords: Ethanol | Potassium channel modulators | Rats | Stomach ulceration

ABSTRACT
Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated.

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