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Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin

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Author(s): Kazue Takahashi | Wei-Chuan Chang | Patience Moyo | Mitchell R. White | Parool Meelu | Anamika Verma | Gregory L. Stahl | Kevan L. Hartshorn | Vijay Yajnik

Journal: Open Journal of Immunology
ISSN 2162-450X

Volume: 01;
Issue: 02;
Start page: 41;
Date: 2011;
Original page

Keywords: Mannose-Binding Lectin | Fructose | Influenza A Virus | Staphylococcus Aureus | Complement | Coagulation

ABSTRACT
Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose down regu-lates MBL-mediated innate immune mechanisms against both influenza A virus (IAV) and Staphy-lococcus aureus. These mechanisms include the lectin complement pathway and coagulation enzyme-like activities on both pathogens. Fur-thermore, fructose also reduces MBL-mediated phagocytosis of S. aureus and IAV and MBL- mediated IAV infection to epithelial cells. In contrast, sucrose inhibits MBL-mediated im-mune mechanisms against S. aureus but not IAV. Together, our studies show that dietary sugars, in particular fructose, negatively regulate the innate immunity against viral and bacterial pathogens.
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