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Differentiation of cochlear neural progenitors with SV40 in vitro

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Author(s): Ling Feng | Yuki Hamajima | Masahiro Komori | John Anderson | Dong Wang | Terry C. Burns | Catherine M. Verfaillie | Walter C. Low | Jizhen Lin

Journal: Molecular and Cellular Pharmacology
ISSN 1938-1247

Volume: 1;
Issue: 1;
Start page: 11;
Date: 2009;
Original page

Keywords: Cochlear neural progenitor | SV40 | Growth factor | Differentiation | Mouse

ABSTRACT
Sphere-forming cochlear stem cells/progenitors have recently been isolated from the postnatal mouse organ of Corti. However, self-renewal of the cochlear progenitors remains to be elucidated. Here we demonstrate the renewable cochlear neural progenitors from the postnatal Immortomouse organ of Corti containing a temperature-sensitive SV40 that have the potential to differentiate into hair cell-, neuron-, and supporting cell-like phenotypes under the guidance of sonic hedgehog, epidermal growth factor, retinoic acid, and brain-derived neurotrophic factor, herein termed SERB. This work provides a rationale for using cochlear neural progenitors in possible cell replacement of lost hair cells and neurons in degenerative hearing disorders.

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