Academic Journals Database
Disseminating quality controlled scientific knowledge

Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities

Author(s): Marumoto Kohei | Koyama Tetsuo | Hosomi Masashi | Kodama Norihiko | Miyake Hiroji | Domen Kazuhisa

Journal: Fluids and Barriers of the CNS
ISSN 2045-8118

Volume: 9;
Issue: 1;
Start page: 20;
Date: 2012;
Original page

Keywords: Diffusion tensor imaging | Fractional anisotropy | Idiopathic normal pressure hydrocephalus | Parkinson’s disease | White matter

Abstract Background Gait abnormalities in the elderly, characterized by short steps and frozen gait, can be caused by several diseases, including idiopathic normal pressure hydrocephalus (INPH), and Parkinson’s disease (PD). We analyzed the relationship between these two conditions and their association with gait abnormalities using laboratory test data and findings from diffusion tensor imaging (DTI). Methods The study involved 10 patients with INPH, 18 with PD, and 10 healthy individuals (control group). Fractional anisotropy (FA) of five brain areas was measured and compared among the three groups. In addition, the association of INPH and PD with gait capability, frontal lobe function, and FA of each brain area was evaluated. Results The INPH group had significantly lower FA for anterior thalamic radiation (ATR) and forceps minor (Fmin) as compared to the PD group. The gait capability correlated with ATR FA in the INPH and PD groups. We found that adding DTI to the diagnosis assisted the differential diagnosis of INPH from PD, beyond what could be inferred from ventricular size alone. Conclusions We expect that DTI will provide a useful tool to support the differential diagnosis of INPH and PD and their respective severities.
Why do you need a reservation system?      Save time & money - Smart Internet Solutions