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Digital Operation of Microelectronic Circuits Analogous to Protein Hydrogen Bonding Networks

Author(s): Elitsa Gieva | Rostislav Rusev | George Angelov | Marin Hristov | Tihomir Takov

Journal: International Journal Bioautomation
ISSN 1314-1902

Volume: 16;
Issue: 4;
Start page: 291;
Date: 2012;
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Keywords: Hydrogen Bonding Networks (HBNs) | Proteins | β-lactamase | Behavioral modeling | Verilog-A

Two hydrogen bonding networks with water molecules and branching residues extracted from β-lactamase protein are investigated and their proton transfer characteristics are studied by creating analogous electrical circuits consisting of block-elements. The block-elements and their proton transfer are described by polynomials that are coded in Matlab and in Verilog-A for use in the Spectre simulator of Cadence IC design system. DC and digital pulse analyses are performed to demonstrate that some circuit outputs behave as repeaters while other - behave as inverters. The results also showed that the HBN circuits might behave as a D-latch and a demultiplexer.
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