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DIHYDRODIPYRIDOPYRAZINES: SYNTHESIS AND FUNCTIONALIZATION

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Author(s): Stéphanie Blanchard | Irina Grig-Alexa | Oana-Irina Patriciu | Adriana Fînaru | Gérald Guillaumet

Journal: Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry
ISSN 1582-540X

Volume: 11;
Issue: 1;
Start page: 45;
Date: 2010;
Original page

Keywords: dihydrodipyridopyrazines | hetarynic cyclization | Pd catalysis | Alkylation | reduction | Cyclization | Smiles rearrangement | dipyridinylamines

ABSTRACT
Different conceptual synthetic approaches to the elaboration of a new family of planar polynuclear nitrogen containing aromatic heterocycles – the dihydrodipyridopyrazines – are reviewed: the arynic reaction, the sequence palladium coupling reaction - substitution - reduction - cyclization - substitution or through the intermediacy of Smiles rearrangement. Further functionalization of these compounds by substitution reaction, metalation sequence and palladium-catalyzed coupling reaction are also discussed.
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