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Disease-Free Survival of Postoperative Gastric Cancer Patients:

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Author(s): H Kashani | M Mahmoodi | H Zeraati | A Rahimi | A Jalali

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 8;
Issue: 4;
Start page: 51;
Date: 2011;
Original page

Keywords: Survival | Competing Risks | Cumulative Incidence Function | Stomach cancer | Iran

ABSTRACT
Background and Aim: Many researchers have studied survival (time to death) of gastric cancer patients. Although gastric cancer diagnosed in early stages can be cured by surgery, chance of relapse still exists after operation. Hence, we should consider both events, that is, relapse of the disease and death, in order to be able to make a more precise estimation for survival of the patients. The purpose of this study was to use the competing risks method to estimate the cumulative incidence functions (CIF) of the relapse of disease and death and consequently to estimate the postoperative disease-free survival. Materials and Methods: A total of 330 patients admitted to Iran Cancer Institute and operated between March 1995 and March 1999 were enrolled in the study. They were followed up for at least 5 years to estimate their 5-year disease-free survival. Information on their demographic, clinical, and therapeutic characteristics, as well as on the type and time of occurrence of the first event (relapse of disease or death) after surgery was collected from their medical records. The direct parametric method was applied to estimate CIFs of relapse of the disease and death, while to adjust the effects of some covariates the parametric regression model was used. Data analysis was done using the R software and a p-value
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