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Diuretic activity of extracts of Centratherum anthelminticum

Author(s): Koti B | Purnima A

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 2;
Issue: 4;
Start page: 228;
Date: 2008;
Original page

Keywords: Centratherum anthelminticum | diuretic activity | electrolyte excretion | hypertension | spiranolactone

In the present study petroleum ether, chloroform and alcohol extracts of Centratherum anthelminticum (L.) Kuntze (family: Asteraceae) seeds (200 mg/kg b.w., p.o.) were tested for diuretic activity. The animals were grouped into five of six animals each. All the animals received priming dose of 0.9% sodium chloride solution (25 ml/kg b.w.). The first group served as control and the second group received the standard drug spiranolactone (20 mg/kg body weight) in 0.9% sodium chloride solution. The other three groups received petroleum ether, chloroform, and alcohol extracts of C. anthelminticum seeds in a dose of 200 mg/kg body weight suspended in 0.9% sodium chloride solution (p.o.). Urine volume was recorded for all the groups for 5 h. The highest diuretic activity was presented by alcohol extract followed by that of chloroform, petroleum ether extract has no significant diuretic activity. Alcohol and chloroform extracts significantly decreased K+ excretion. We observed a potent diuretic and electrolyte excretion activity of chloroform and alcohol extracts of C. anthelminticum seeds. These findings suggest the possible traditional use of this plant in hypertension as diuretics are used in the management of hypertension.
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