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DNA CLEVAGE STUDIES OF THE ETHANOLIC EXTRACTS OF THE BARK OF BAUHINIA TOMENTOSA L. AND THE WHOLE PLANT OF MUSSAENDA FRONDOSA L.

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Author(s): S. Gopalakrishnan | E. Vadivel

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 153;
Date: 2011;
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Keywords: DNA cleavage studies | Bauhinia tomentosa L | Mussaenda frondosa L | pUC18 DNA.

ABSTRACT
DNA cleavage studies of the ethanolic extracts of the bark of Bauhinia tomentosa L. (Fam, Fabaceae) and the whole plant of Mussaenda frondosa L. (Fam, Rubiaceae) have been performed. The cleavage of pUC18 DNA was evaluated by agarose gel electrophoresis. Both the plant extracts show a dose dependent increase from lower concentration to higher concentration. Ethanol extract of Bauhinia tomentosa L showed more cleavage activity than that of the Mussaenda frondosa L. The results have been compared with the standard DNA cleavage agent FeSO4.
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