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DOC and GCA blocks the reduction of hypothalamic CRF containing neurons due to repetitive stress

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Author(s): Suhaimi FH | Mohamad NB | Abdulkadir KB

Journal: Neuroanatomy
ISSN 1303-1783

Volume: 6;
Issue: 1;
Start page: 17;
Date: 2007;
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Keywords: deoxycorticosterone | dexamethasone | glycyrrhizic acid | CRF containing neurons | paraventricular nucleus | repetitive stress

ABSTRACT
Stress causes multiple adaptive hormonal responses including the secretion of CRF, ACTH and corticosteroids.These responses to repetitive stress could be blocked by naloxone, corticosteroids and glycyrrhizic acid (GCA).The effect of corticosteroids and GCA on the hypothalamic CRF containing neurons with repetitive stress hasnot been studied. Sprague-Dawley rats were given either dexamethasone (DEX), deoxycorticosterone (DOC) or GCA. On theeleventh day of treatment, the rats were exposed to two hours of immobilization stress and the procedure wasrepeated daily for another twelve days. The rats were sacrificed on days 2, 4, 8 and 12 after immobilization.On the days of sacrifice, the rats were transfused transcardially and the hypothalami were dissected forimmunohistochemical analysis. With repetitive stress, the number of CRF containing neurons decreased significantly from 1631 ± 58 neurons/mm2 to 595 ± 71 neurons/mm2 (p

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